• The 135th WPI-IIIS seminar

    07 04, 2018

    Date July 4, Wednesday, 2018
    Time 12:00 –13:00
    Venue 1F Auditorium, IIIS Building, University of Tsukuba
    Access Take a bus bound for "Tsukuba Daigaku Chuo" or the "University Loop-line On-campus Bus [Tsukuba Daigaku Junkan Bus]" and get off at Oikoshi Gakusei Shukusha Mae
    Speaker Dr. Yukiko Gotoh, Department of Pharmaceutical Sciences, The University of Tokyo
    Subject Regulation of neural stem/progenitor cell fate during neocortical development
    Summary A fundamental question in understanding tissue development is how resident stem cells or multipotent progenitors give rise to the various cell types in appropriate numbers and at the right locations to achieve tissue organization. Neural stem/progenitor cells (NPCs) in the mammalian neocortex initially divide symmetrically to increase their pool size (expansion phase). They then divide asymmetrically and give rise to neuronal and glial cell types in a region- and developmental stage–dependent manner and with high precision (neurogenic and gliogenic phases, respectively). We have previously shown that Polycomb group (PcG) complex and high mobility group A (HMGA) proteins play pivotal roles in driving the fate switches of NSCs associated with the transition from the neurogenic phase to the gliogenic phase. At this seminar, I would like first to focus on how these and other proteins control the fate of NPCs. Second, I will address the mechanisms underlying the transition from the expansion phase to the neurogenic phase and discuss their potential role in psychiatric diseases such as autism spectrum disorder.

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