A proton is a positively charged elementary particle. When a high energy proton penetrates the body, it stops completely at a certain depth forming a very sharp Bragg peak ionization. Thus, proton radiotherapy is one of the most advanced methods of treating tumors enabling us to irradiate the targets while keeping adjacent normal tissue/organs almost undamaged. The missions of PMRC are; 1) to prove these clinical advantages and efficacy of proton beam therapy, 2) to develop innovative treatment technologies for fast and accurate treatment, 3) to clarify specific biological effects of protons for future clinical application, all aimed at developing optimal treatments for cancer patients.
We are also committed to teaching students at graduate and post-graduate levels as well as residents in radiation oncology. Our goal is to educate future world-class leaders in all academic and/or clinical fields of proton beam radiotherapy.
Research is an essential part of PMRC's mission. Research in the fields of clinical medicine, physics, and biology are conducted to pursue optimal modalities for curing cancer patients safely as well as completely. Proton therapy will likely become the cancer treatment of choice for many patients with suitable clinical research. The future of proton therapy depends heavily on extensive research in these fields over the coming years.
1) We conduct clinical research in various cancers including hepatic cancers, pediatric malignancies, lung cancers, prostate cancers. Also, a clinical trial in arteriovenous malformation of the brain is currently in progress. All are aimed to accumulate reliable levels of evidence of PBT.
2) We analyze the efficacy of proton beam radiotherapy not only on refractory or unresectable tumors but also on more common solid tumors based on its robust clinical efficacy.
3) We also investigate the efficacy of proton radiotherapy concurrent with chemo or molecular targeting therapy to improve the outcomes of cancer patients.
1) We explore and develop radiation treatment techniques for optimum physical dose conformation to the tumor target volume.
2) We develop methods to consider the time and motion components in the whole radiotherapy process from imaging over beam delivery.
3) We perform Monte Carlo simulations to increase the accuracy of the dose prediction.
4) For treatment optimization, we model the relationship between dose distribution and clinical outcome with a biophysical approach.
1) For treatment optimization, we measure and model the relative biological effectiveness of protons.
2) We investigate cellular and molecular mechanisms of action of proton beams with the overall goal of clinical application to improve cancer treatment, especially to find novel molecular targets for sensitizing proton radiotherapy.
3) We aim to develop an approach to combining proton radiotherapy and immunotherapy using novel immune adjuvant and immune cells.
Division: Office of Proton Medical Research Center
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Proton Medical Research Center Website(Japanese)
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