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447th TSMM seminar
(This presentation will be held in English)

2018/12/27

Title: Macrophages and osteoclasts in the regulation of haematopoietic niches

Speaker:Dr. Stuart Fraser
      Associate Professor
      Disciplines of Physiology, Anatomy & Histology School of Medical Sciences, University of Sydney

Date:Dec 27th, 2018(Thu)17:00-18:30

Place:Igaku Gakkei-to Room 483 GooglrMap版へ
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 利用停留所(関東鉄道バス):筑波大学中央行き又は筑波大学循環バス「追越学生宿舎前

Abstract:
Haematopoiesis, or “the crafting of the blood”, begins in the yolk sac then moves to various locations throughout the developing embryo until the bones form and a life-long niche for blood production is established. We have found specialised macrophage populations playing roles in the haematopoietic niches throughout development and during physiological stress. In the yolk sac, we have identified a previously unreported macrophage population residing on the outermost layer which is developmentally regulated and may re-model the yolk sac absorptive epithelial layer, which in turn stimulates haematopoiesis. In the bone marrow, we have focused on exploring the interactions between central macrophages and the erythroblasts which surround them, in multicellular structures termed erythroblastic islands. Detailed analyses of erythroblastic islands at the nanometer scale have revealed cell-cell interactions and developmental pathways that had not previously been observed. This led us to ask whether all bones are equally able to support blood production. In exploring this, we have found that anaemic stress leads to profound changes in osteoclast gene expression demonstrating that specialised macrophages play important roles in establishing and maintaining the haematopoietic niche throughout life.

本セミナーは、生命システム医学専攻&疾患制御医学専攻(博士)「医学セミナー」(担当:専攻各教員)、及び、フロンティア医科学専攻(修士)「医科学セミナーII」(担当:入江賢児)の関連セミナーに相当します。

連絡先: 筑波大学医学医療系 高橋 智
Tel:029-853-7516
Mail:satoruta#@#md.tsukuba.ac.jp(#@#を 「@」 に置き換えてください)

【筑波分子医学協会(TSMM)主催】 HP http://www.md.tsukuba.ac.jp/public/tsmm/

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