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《医学セミナー》60th Tsukuba Immunology Seminar Antigen-specific expansion and differentiation of natural killer cells by alloantigen stimulation

2014/11/18

Seminar in Medical Sciences 《医学セミナー》ご案内

This seminar will be held in English

◆共催:TARAセミナー/第60回免疫学セミナーのお知らせ◆

【演題】

Antigen-specific expansion and differentiation of natural killer cells by alloantigen stimulation

【講師】

Tsukasa Nabekura, Ph.D.

【所属】

Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, U.S.A.

/Life Science Center, Tsukuba Advanced Research Alliance, University of Tsukuba, Japan

【日時】

平成261118日(火)午後1700-1815

【場所】

Seminar room, Building A, TARA CenterGooglrMap版へ
【講演要旨】

Natural killer (NK) cells provide important host defense against microbial pathogens.  Recently, we have demonstrated that NK cells can generate long-lived memory NK cells after cytomegalovirus infection in mice and humans.  Here, we addressed whether NK cells can expand and differentiate after alloantigen stimulation, which may be important in hematopoietic stem cell transplantation.  A subset of NK cell in C57BL/6 mice expresses the activating Ly49D receptor that is specific for H- 2Dd.  These Ly49D+ NK cells can preferentially expand and differentiate when challenged with allogeneic H-2Dd+ cells in the context of an inflammatory environment.  H-2Dd is also recognized by the inhibitory Ly49A receptor, which when co-expressed on Ly49D+ NK cells suppresses the expansion of Ly49D+ NK cells.  Specificity of the secondary response of alloantigen-primed NK cells was defined by the expression of activating Ly49 receptors.  Thus, the summation of signals through a repertoire of Ly49 recept

ors controls the adaptive immune features of NK cells responding to allogeneic cells.

 

セミナーは英語で行われます

This seminar will be held in English

 

事前登録:否 No registration is required.

参加費: 無 Free

問合せ先: 医学医療系・免疫学

渋谷 彰 ashibuya#@#md.tsukuba.ac.jp (#@#を@に置き換えてください)

029-853-3281

 

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