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World Science Leader’s Seminar “Microfluidics Design for Unmet Medical Needs” (Human Biology Program)

2015/07/14

2015年7月14日に筑波大学「ヒューマンバイオロジー学位プログラム」が主催となり、World Science Leader’s Seminarを開催いたします。World Science Leader’s Seminarは,サイエンスの世界で活躍されている方々にお越しいただき,トップレベルの知識と技術をご指導いただく貴重な機会です。今回の講演者はDr. Han-Yi E. Chou (Assistant Professor, National Taiwan University)です。どなたでも参加可能ですので,ふるってご参加ください。尚,本セミナーは英語で行われます。

開催日時:2015年7月14日(火)10:10~11:25
会 場 :医学学群等 4A411GooglrMap版へ
アクセス:
筑波大学筑波キャンパスへは「筑波キャンパスへの交通アクセス」をご覧ください。
利用停留所(関東鉄道バス):筑波大学中央行き又は筑波大学循環バス「追越学生宿舎前

ゲストスピーカー:Dr. Han-Yi E. Chou (Assistant Professor, National Taiwan University)
セミナータイトル:Microfluidics Design for Unmet Medical Needs
アブストラクト:
The advent of personalized medicine brought exiting innovations in health care and research, however, the difficulty of specimen manipulation at miniature scales soon emerged as a primary constrain, as subject derived samples should always be minimalized as to preserve donor integrity and to enable longitudinal analyses. To tackle with this problem, microfluidics engineering offers great opportunities by providing theoretical analyses and maneuvering technology at nano- and microliter sizes. Here, we describe the design and fabrication of a microfluidic device for bed-side fractionation of minute mass specimen, featuring temperature control, bicarbonate dependent pH regulation, and a pH responsive chitosan coating to discriminate cancer metastatic potential through absorption of fibronectin. It is well reported that lung cancer metastatic potential is positively correlated with the amount of fibronectin expression in the cancerous cells. We show that cell absoption/detachment in our design correlates with the migratory ability of lung and oral squamous cell carcinoma upon change of physiologically permissible range of environmental pH, without the need of cell culture facilities and time-consuming maneuvers for the assay. The working scale requires minimal amount of cells, which may be obtained by operation and even biopsy. The second example is an enabling demonstration of open-surface droplet manipulation, which explores the dynamicity of droplet behavior to couple with matching-score dependent hybridization to drive controlled growth of nanogold structures. Systematic
comparison of the different possible matchings then lead to a colorimetric read out that can be judged with the naked sight. Using this concept, we are now developing an application to copes with the concept of homecare diagnosis coupled with cloud sourcing to solve the unmet medical need of early detection of drug resistance in cancer.

主催:筑波大学 ヒューマンバイオロジー学位プログラム & グローバルイノベーション学位プログラム
連絡先
住所 〒305-8577 茨城県つくば市天王台1-1-1
総合研究棟A グローバル教育院事務室
Mail sigma#@#un.tsukuba.ac.jp(#@#を 「@」 に置き換えてください)
TEL 029-853-7085

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