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World Science Leader’s Seminar “DNA damage-induced chromatin regulation and DNA repair pathway choice” (Human Biology Program)

2015/07/28

2015年7月28日に筑波大学「ヒューマンバイオロジー学位プログラム」が主催となり,World Science Leader’s Seminarを開催いたします。World Science Leader’s Seminarは,サイエンスの世界で活躍されている方々にお越しいただき,トップレベルの知識と技術をご指導いただく貴重な機会です。今回の講演者はDr. Kyoko Yokomori (Professor, University of California, Irvine)です。どなたでも参加可能ですので,ふるってご参加ください。尚,本セミナーは英語で行われます。

開催日時:2015年7月28日(火)8:40~10:10
会 場 :医学学群棟 4A 204GooglrMap版へ
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筑波大学筑波キャンパスへは「筑波キャンパスへの交通アクセス」をご覧ください。
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ゲストスピーカー:Dr. Kyoko Yokomori (Professor, University of California, Irvine)
セミナータイトル:DNA damage-induced chromatin regulation and DNA repair pathway choice
アブストラクト:
DNA damage is constantly induced during normal cellular respiration, by errors that arise during DNA replication and recombination, and by exogenous exposure to DNA damaging agents. If not faithfully repaired, these genomic insults can lead to persistent lesions ranging from single nucleotide changes to chromosome rearrangement or loss, resulting in cancer, developmental abnormalities, and cell death. Different types of DNA damage are recognized by lesion-specific repair factors, which invoke distinct repair pathways such as nucleotide excision repair (NER), base excision repair (BER), and double-strand break (DSB) repair. How their activities are coordinated in the cell nucleus is still not well understood. In vivo, DNA is organized in the form of chromatin by interacting with histones and other factors, and it is widely acknowledged that regulation of chromatin structure is of paramount importance for DNA metabolism. DNA damage signaling and repair pathway choice appears to be critically influenced by local chromatin structure at damage sites. Technical advances in recent years, including laser microirradiation and endonuclease-mediated DSB induction systems, have led to further understanding of DNA damage response and repair processes as they occur in vivo as well as discovery of previously unrecognized roles for chromatin remodeling factors, histone chaperones and histone modifying enzymes in DNA repair. Evidence suggests that chromatin at damage sites undergoes dynamic structural changes during the repair process, with transient intervals of “closed” configurations prior to more “open” arrangements that allow the repair machinery to access damaged DNA. In this lecture, I will discuss the experimental tools used to explore mammalian DNA repair mechanisms and summarize recent unexpected findings on chromatin regulation in DNA damage signaling and repair in vivo, with particular emphasis on damage-induced recruitment of heterochromatin factors and the critical roles of phosphatidylinositol 3-kinase-related kinase (PIKK) and poly(ADP-ribose) polymerase (PARP) signaling in damage-induced chromatin reorganization and DNA repair pathway choice in the maintenance of genome integrity.
主催:筑波大学 ヒューマンバイオロジー学位プログラム & グローバルイノベーション学位プログラム
連絡先
住所 〒305-8577 茨城県つくば市天王台1-1-1
総合研究棟A グローバル教育院事務室
Mail sigma#@#un.tsukuba.ac.jp(#@#を 「@」 に置き換えてください)
TEL 029-853-7085

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