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World Science Leader’s Seminar “Obesogens, Stem Cells and the Transgenerational Programming of Obesity” (Human Biology Program)

2015/10/21

2015年10月21日に筑波大学「ヒューマンバイオロジー学位プログラム」が主催となり,World Science Leader’s Seminarを開催いたします。

World Science Leader’s Seminarは,サイエンスの世界で活躍されている方々にお越しいただき,トップレベルの知識と技術をご指導いただく貴重な機会です。今回の講演者はDr. Bruce Blumberg (Professor, Department of Developmental and Cell Biology University of California, Irvine)です。どなたでも参加可能ですので,ふるってご参加ください。尚,本セミナーは英語で行われます。

開催日時:2015年10月21日(水)17:00 – 18:30

会 場 :医学学群棟 4A 411GooglrMap版へ
アクセス:
 筑波大学筑波キャンパスへは「筑波キャンパスへの交通アクセス」をご覧ください。
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ゲストスピーカー:
Dr. Bruce Blumberg (Professor, Department of Developmental and Cell Biology University of California, Irvine)

セミナータイトル:
Obesogens, Stem Cells and the Transgenerational Programming of Obesity

アブストラクト:
In the last three decades there has been a dramatic, worldwide increase in the incidence of obesity, particularly in Western societies. This trend has required a significant economic investment to treat obesity-related disorders such as type 2 diabetes, cardiovascular disease, and non-alcoholic fatty liver disease. There is an urgent need to understand the factors that contribute to this increase in obesity in order to find new tools that will improve quality of life in affected individuals and to avoid the propagation of obesity to future generations. The generally accepted cause of obesity is overconsumption of calorie-dense food and diminished physical activity (the calories in – calories out model). However, emerging evidence demonstrates that environmental factors can predispose exposed individuals to gain weight, irrespective of diet and exercise. The environmental obesogen model proposes that chemical exposure during critical stages in development can influence subsequent adipogenesis, lipid balance and obesity. Obesogens are chemicals that inappropriately stimulate adipogenesis and fat storage. Numerous obesogens have been identified in recent years and some of these have been shown to act through the peroxisome proliferator activated receptor, the master regulator of adipogenesis. Others act through as yet unidentified pathways. Notably, some of these obesogens elicit transgenerational effects on a variety of health endpoints, including obesity in offspring through the F4 generation after exposure of pregnant F0 females. Thus, prenatal exposure to xenobiotic compounds can have lasting, potentially permanent effects on the offspring of exposed animals. Transgenerational effects of chemical exposure raise the stakes in the debate about whether and how endocrine disrupting chemicals should be regulated.

主催:筑波大学 ヒューマンバイオロジー学位プログラム & グローバルイノベーション学位プログラム

連絡先
住所 〒305-8577 茨城県つくば市天王台1-1-1 総合研究棟A グローバル教育院事務室
Mail sigma@un.tsukuba.ac.jp
TEL 029-853-7085

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