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第135回WPI-IIISセミナー

2018/07/04

日 時:平成30年7月4日(水) 12:00-13:00

場 所:筑波大学 医学系エリア 睡眠医科学研究棟 1F 講堂 GooglrMap版へ
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 利用停留所(関東鉄道バス):筑波大学中央行き又は筑波大学循環バス「追越学生宿舎前

演者: Dr. Yukiko Gotoh (後藤 由季子 先生)
     Department of Pharmaceutical Sciences, The University of Tokyo
    (東京大学大学院 薬学系研究科)

演題: “Regulation of neural stem/progenitor cell fate during neocortical development“

要旨: A fundamental question in understanding tissue development is how resident stem cells or multipotent progenitors give rise to the various cell types in appropriate numbers and at the right locations to achieve tissue organization. Neural stem/progenitor cells (NPCs) in the mammalian neocortex initially divide symmetrically to increase their pool size (expansion phase). They then divide asymmetrically and give rise to neuronal and glial cell types in a region- and developmental stage–dependent manner and with high precision (neurogenic and gliogenic phases, respectively). We have previously shown that Polycomb group (PcG) complex and high mobility group A (HMGA) proteins play pivotal roles in driving the fate switches of NSCs associated with the
transition from the neurogenic phase to the gliogenic phase. At this seminar, I would like first to focus on how these and other proteins control the fate of NPCs. Second, I will address the mechanisms underlying the transition from the expansion phase to the neurogenic phase and discuss their potential role in psychiatric diseases such as autism spectrum disorder.

詳細はこちらからもご覧になれます:http://wpi-iiis.tsukuba.ac.jp/japanese/seminar

問い合わせ:国際統合睡眠医科学研究機構 029-853-8080(内線8080)

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