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第147回WPI-IIISセミナー

2019/04/10

日時:平成31年4月10日(水) 12:00-13:00

場所:筑波大学 医学系エリア 睡眠医科学研究棟 1F 講堂GooglrMap版へ
アクセス:「筑波大学筑波キャンパスへの交通アクセス」をご覧ください。
利用停留所(関東鉄道バス):筑波大学中央行き又は筑波大学循環バス「追越学生宿舎前

演者: Dr. Takayasu Mikuni (三國 貴康先生)
      Brain Research Institute, Niigata University(新潟大学)

演題: “Genome Editing in Mammalian Brain in vivo: Key Technologies and Future Applications”

要旨:Rapid and precise genome editing using CRISPR-Cas systems is a powerful technology in various scientific fields. Especially, genome editing through homology-directed repair (HDR) provides a versatile approach to precisely introduce insertions, deletions or replacements in the genome. However, it has been considered to be difficult to induce HDR in postmitotic neurons, limiting the application of precise genome editing in the field of neuroscience. Here Dr. Mikuni presents two strategies, SLENDR and vSLENDR, to induce HDR- mediated genome editing in mammalian brain in vivo (Cell 2016, Neuron 2017). Rapid and precise genome editing in the brain will allow for a wide range of applications in neuroscience research, such as high-throughput monitoring and manipulation of endogenous gene products in brain tissue.

詳細はこちらからもご覧になれます:
http://wpi-iiis.tsukuba.ac.jp/japanese/seminar

問い合わせ:国際統合睡眠医科学研究機構
      029-853-8080(内線8080)

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