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第148回、第149回、第150回 WPI-IIISセミナー

2019/04/15

日 時:平成31年4月15日(月)
第148回 WPI-IIIS セミナー(14:05-14:50)
第149回 WPI-IIIS セミナー(15:00-15:45)
第150回 WPI-IIIS セミナー(15:55-16:40)
※筑波大学 国際統合睡眠医科学研究機構(WPI-IIIS) 「ヒト睡眠研究施設(Human Sleep Lab)」開所記念式典の第一部として開催

場 所:筑波大学 医学系エリア 睡眠医科学研究棟 1F 講堂 GooglrMap版へ
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第148回WPI-IIIS Seminar

演者:Dr. Kingman P. Strohl ( Departments of Medicine, Physiology & Biophysics, and Oncology, Case Western Reserve University )
演題: “Mechanisms of Current and Emerging OSA Therapy”
要旨: Obstructive sleep apnea (OSA) is the appearance of recurrent apneas and hypopneas during sleep. It is a complex syndrome with a causal mechanism of airway closure or near closure, due to a reduced muscle tone during sleep. A second element is the gain of the system, when at termination there occurs an excessive ventilatory overshoot (a high gain), and then recovery leads to a fall back below a threshold for keeping the airway open. Another contribution is poor recruitment of drive to muscles involved in reopening an obstructed airway, and sleep itself, i.e. a tendency for early arousal from sleep. Treatment can bypass any obstruction with a tracheostomy or, if it is nasopharyngeal obstruction, place a flexible tube through one nasal passage with Nastent (Seven Dreamers). Continuous positive airway pressure (CPAP) or oral appliances stent the airway open. Surgery on the anatomy or weight loss also lower the tendency for airway closure. A new approach is to directly stimulate the hypoglossal nerve and actively open the airway, leaving anatomy and loop gain alone. Future directions being studied are pharmacologic approaches that can prevent the loss of muscle tone with sleep, lower loop gain, and/or prevent early arousals, while promoting sleep; however, no drugs have reached a regulatory threshold.

第149回WPI-IIIS Seminar

演者:Dr. Marry J. Morrell ( Sleep and Respiratory Physiology, Imperial College London )
演題:“Roles of Reward and Inhibitory Control in Perceptual Learning”
要旨:Sleep is something we all do; in fact it is vital for survival. This talk will focus on the impact of apnea during sleep and its treatment. We all sleep differently. Madonna has revealed she ‘only grabs four hours sleep a night because she constantly worries about everything in her life’ (BBC news). So what happens if we don’t get enough? And should we treat people who cannot sleep due to apnea? Indeed should we treat apnea that does not cause sleepiness? These questions will be discussed, taking account of recently published research and ongoing treatment trials.

第150回WPI-IIIS Seminar

演者:Dr. Shigenobu Shibata (柴田 重信先生) ( School of Advanced Science and Engineering, Waseda University(早稲田大学) )
演題:“Timing effect of intake of inulin containing food/ vegetables on blood glucose level, cecal short chain fatty acids and microbiota in mice and humans”
要旨:Inulin, a water-soluble dietary fiber is used for health claims such as lowering effect of glucose and/or lipid absorption. Artichoke and burdock roots highly contain inulin (50-30% of dry powder). It is well known that blood glucose level (BGL) by same meal is dependent on the meal time; dinner BGL is higher than breakfast BGL. Artichoke powder at breakfast in human experiments lowered the 24-hr BGL, and also lunch- and dinner-induced BGL, as a second meal effect. Artichoke at breakfast provide good effect on bowel movement, and cecal microbiota, suggesting the importance of eat timing on BGL and microbiota.

詳細はこちらからもご覧になれます

http://wpi-iiis.tsukuba.ac.jp/japanese/seminar

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国際統合睡眠医科学研究機構
029-853-8080(内線8080)

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