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第156回WPI-IIISセミナー

2019/08/19

日 時:2019年8月19日(月) 12:00-13:00

場 所:筑波大学 医学系エリア 睡眠医科学研究棟 1F 講堂GooglrMap版へ
アクセス:「筑波キャンパスへの交通アクセス」をご覧ください。
利用停留所(関東鉄道バス):筑波大学中央行き又は筑波大学循環バス「追越学生宿舎前

演者: Dr. Haruki Takeuchi (竹内 春樹 先生)
Graduate School of Pharmaceutical Sciences, The University of Tokyo
(東京大学大学院 薬学研究科)

演題:“Cell-type-specific patterned activities specify gene expression patterns for olfactory circuit formation -Neurons that fire in the same pattern wire together-”

要旨: The development of precise neural circuits is initially directed by genetic programming and subsequently refined by electrical neural activity. The most prevailing model for the activity-dependent development of neural circuits postulates the interaction between pre- and post-synaptic neurons. In Hebbian plasticity, the correlated activity of pre- and post-synaptic neurons strengthens synaptic connections, whereas uncorrelated or lack of activity weakens them. However, the olfactory map develops even in mutant mice lacking synaptic partners, suggesting another mechanism for the olfactory map formation. In this seminar, I would like to propose a novel activity-dependent mechanism in which cell-type-specific patterned activity contributes to the olfactory map refinement through orchestrating gene expression of various axon-sorting molecules.

詳細はこちらからもご覧になれます:http://wpi-iiis.tsukuba.ac.jp/japanese/seminar
問い合わせ:国際統合睡眠医科学研究機構 029-853-8080(内線8080)

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