This seminar is regarded as a lecture for the subject "Seminar in Medical Sciences"
|Date / Time||April 20, 2017 17:00-18:30|
|Venue||Seminar Room 105 (Health and Medical Science Innovation building 1st floor)|
|Speaker||Dr. Andrea Corsinotti
Laboratory of Embryonic Stem Cell Biology MRC Centre for Regenerative Medicine University of Edinburgh/ University of Tsukuba
|Title||Differential SoxB1 requirements in naïve and primed pluripotency.|
|Abstract||Sox2 is a key transcription factor directing embryonic stem cell (ESC) pluripotency. Self-renewal of Sox2-/- ESCs can be rescued by the SoxB1 proteins Sox1 or Sox3. However, the role of SoxB1 proteins in epiblast stem cell (EpiSC) pluripotency is unknown. We compared the abilities of Sox2-related proteins to maintain pluripotency in these cell types. Surprisingly, deletion of Sox2 from EpiSCs does not eliminate self- renewal but Sox3 levels are increased. While EpiSCs can also dispense with Sox3, deletion of both Sox2 and Sox3 prevents self-renewal. ESCs with altered SoxB1 levels exhibit differentiation defects. We demonstrate that a redundant SoxB1 function maintains pluripotency in ESCs and EpiSCs, with SoxB1 levels controlling the ability of ESCs to be captured as EpiSCs or escape pluripotency.|
|Contact||Professor Satoru Takahashi
Faculty of Medicine, University of Tsukuba
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