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  • World Science Leader's Seminar "Nuclear Translocation of PKCalpha is Associated with Cell Cycle Arrest and Erythroid Differentiation in Myelodysplastic Syndromes (MDS)" (Ph.D. Program in Human Biology)

    10 13, 2017

    Date / Time Fri. October 13, 2017
    Place Room 301, Health and Medical Science Innovation Laboratory, the University of Tsukuba
    Access Take a bus bound for "Tsukuba Daigaku Chuo" or the "University Loop-line On-campus Bus [Tsukuba Daigaku Junkan Bus]" and get off at Oikoshi Gakusei Shukusha Mae.
    Speaker Dr. Lucio Cocco (Cellular Signaling Laboratory, Department of Biomedical Sciences, University of Bologna)
    Seminar Title Nuclear Translocation of PKCalpha is Associated with Cell Cycle Arrest and Erythroid Differentiation in Myelodysplastic Syndromes (MDS)
    Abstract PI-PLCbeta1 is involved in cell proliferation, differentiation and MDS pathogenesis. Moreover, the increased activity of PI-PLCbeta1 reduces the expression of PKCalpha that, in turn, delays the cell proliferation and is linked to erythropoiesis. Lenalidomide is currently used in del(5q)low-risk MDS patients, where it can suppress the del(5q)clone and restore a normal erythropoiesis. We studied the effect of Lenalidomide on 16 low-risk del(5q) MDS patients, as well as del(5q) and non-del(5q) hematopoietic cell lines, mainly focusing on erythropoiesis, cell cycle and PI-PLCbeta1/PKCalpha signalling. Responder patients and del(5q)cells showed a specific induction of erythropoiesis and a nuclear translocation of PKCalpha. Moreover, Lenalidomide could induce a selective G0/G1 arrest of cell cycle in del(5q) cells, slowing down the rate proliferation of these cells.
    Language English
    Eligible Participants The seminar is open to all.
    Organizer Ph. D. Program in Human Biology, Leading Graduate Doctoral Program, the University of Tsukuba
    Inquiries School of Integrative and Global Majors (SIGMA), the University of Tsukuba
    1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577 JAPAN
    Phone: 029-853-7085 (Ext. 7085)
    Mail: sigma#@#un.tsukuba.ac.jp
    (Remove “#” from the above e-mail address before sending mail.)


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