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  • “Seminars in Medical Sciences” Lecture: Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer

    01 11, 2018

    This seminar will be held in English.

    Date / Time January 11, 2018 (Thurs), 17:00-18:15
    Venue 8F Auditorium, Health and Medical Science Innovation Laboratory, Medical Area, University of Tsukuba
    Access Take a bus bound for "Tsukuba Daigaku Chuo" or the "University Loop-line On-campus Bus [Tsukuba Daigaku Junkan Bus]" and get off at Oikoshi Gakusei Shukusha Mae.
    This seminar is one of the seminars for the subject "Seminar in Medical Sciences" in Doctoral Programs in Biomedical Sciences and Clinical Sciences. The seminar will be given in English, but questions in Japanese are also welcome.
    Speaker Dr. Akihiro Fujimoto(Associate Professor, Department of Drug Discovery Medicine, Graduate School of Medicine, Kyoto University)
    Title Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer
    Abstract Liver cancer, which is most often associated with virus infection, is prevalent worldwide, and its underlying etiology and genomic structure are heterogeneous. Here we provide a whole-genome landscape of somatic alterations in 300 liver cancers from Japanese individuals. Our comprehensive analysis identified point mutations, structural variations (STVs), and virus integrations, in noncoding and coding regions. We discovered recurrently mutated coding and noncoding regions, such as long intergenic noncoding RNA genes (NEAT1 and MALAT1), promoters, and regulatory regions. STV analysis found a significant association with replication timing and identified known (CDKN2A, CCND1, APC, and TERT) and new (ASH1L, NCOR1, and MACROD2) cancer-related genes that were recurrently affected by STVs, leading to altered expression.
    These results emphasize the value of whole-genome sequencing analysis in discovering cancer driver mutations and understanding comprehensive molecular profiles of liver cancer, especially with regard to STVs and noncoding mutations.
    Contact Naoyuki Tsuchiya, Molecular and Genetic Epidemiology Laboratory
    Mail: tsuchiya#@#md.tsukuba.ac.jp
    (Remove "#" from the above e-mail address before sending mail.)

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