|Date / Time||Thursday, January 11, 2018, 12:00-13:00|
|Place||1F Auditorium, IIIS Building, University of Tsukuba|
|Speaker||Dr. Yuji Ikegaya
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
|Subject||"Hippocampal ripples downregulate synaptic weights during slow-wave sleep"|
Synapses are potentiated during awake periods
and are cooled down during sleep, during which long-term depression (LTD) may
also help erase unwanted memory engrams. However, the neural entity that causes
LTD has not yet been identified, even though 40 years have passed since
hippocampal LTD was first described. We discovered that slow-wave ripples
(SWRs) perform this function. The event frequency of SWRs increases up to
approximately 1 Hz after learning and then serves as a low-frequency
stimulation protocol that induces LTD. Through this LTD, SWRs refine neuron
ensembles that are replayed during slow-wave sleep.
Therefore, our findings advocate another new and important role of SWRs whose role was previously known to contribute to memory consolidation.
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|Contact||International Institute for Integrative Sleep Medicine
Phone: 029-853-8080 (ext.8080)
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