• The 243rd Tsukuba Brain Science Seminar

    06 19, 2018

    Date June 19th, 2018 (Tue) 18:00-
    Venue Auditorium, the 8th floor of the Health and Medical Science Innovation Laboratory
    Lecturer Dr. Takatoshi Hikida, Laboratory for Advanced Brain Functions, Institute for Protein Research, Osaka University
    Title Distinct roles of the direct and indirect striatal pathways in cognitive learning
    Language English
    Chairperson Dr. Masayuki Masu, Faculty of Medicine, University of Tsukuba
    Abstract The basal ganglia plays a critical role in motor functions as well as cognitive learning. In the basal ganglia
    network, the inputs of the striatum/nucleus accumbens are transmitted through two parallel direct and indirect pathways and controlled by dopamine transmitter. We have developed transgenic mouse models to dissect neural network mechanisms in cognitive learning. Using reversible neurotransmission blocking (RNB), we developed D-RNB and I-RNB mouse models in which transmission-blocking tetanus toxin was expressed in the direct striatonigral or the indirect striatopallidal pathway and, in turn, blocked each pathway in a doxycycline-dependent manner. We have revealed the distinct role of the two striatal pathways in cognitive learning: the direct pathway critical for reward-based learning and the indirect pathway for aversive learning. We next addressed the regulatory mechanisms of the basal ganglia circuit and showed that the dynamic shift of pathway-specific neural plasticity via selective transmitter receptors and subcellular signaling is essential for reward and aversive learning behavior.

    More detail Tsukuba Brain Science Assosiation (TBSA)

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