• The 133rd WPI-IIIS seminar

    06 20, 2018

    Date and time 20 June 2018, Wednesday, 12:00 - 13:00
    Venue 1F Auditorium, IIIS Building, University of Tsukuba
    Access Take a bus bound for "Tsukuba Daigaku Chuo" or the "University Loop-line On-campus Bus [Tsukuba Daigaku Junkan Bus]" and get off at Oikoshi Gakusei Shukusha Mae
    Speaker Dr. Yulong Li, School of Life Sciences, Peking University, Beijing, China
    Subject Spying on dopamine modulation by constructing new genetically-encoded sensors
    Summary Dopamine (DA) is a central monoamine neurotransmitter involved in many physiological and pathological processes. A longstanding yet largely unmet goal is to measure DA changes reliably and specifically with high spatiotemporal precision, particularly in animals executing complex behaviors. Here we report the development of two genetically-encoded GPCR-Activation-Based-DA (GRAB_DA ) sensors that enable these measurements. GRAB_DA sensors can resolve a-single-electrical-stimulus evoked DA release, and detect endogenous DA release in the intact brains of flies, fish, and mice. Similar strategies can be harnessed to develop a plethora of GRAB sensors for other important neurotransmitters/neuromodulators.

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