|Date and time||20 June 2018, Wednesday, 12:00 - 13:00|
|Venue||1F Auditorium, IIIS Building, University of Tsukuba|
|Access||Take a bus bound for "Tsukuba Daigaku Chuo" or the "University Loop-line On-campus Bus [Tsukuba Daigaku Junkan Bus]" and get off at Oikoshi Gakusei Shukusha Mae|
|Speaker||Dr. Yulong Li, School of Life Sciences, Peking University, Beijing, China
|Subject||Spying on dopamine modulation by constructing new genetically-encoded sensors|
|Summary||Dopamine (DA) is a central monoamine neurotransmitter involved in many physiological and pathological processes. A longstanding yet largely unmet goal is to measure DA changes reliably and specifically with high spatiotemporal precision, particularly in animals executing complex behaviors. Here we report the development of two genetically-encoded GPCR-Activation-Based-DA (GRAB_DA ) sensors that enable these measurements. GRAB_DA sensors can resolve a-single-electrical-stimulus evoked DA release, and detect endogenous DA release in the intact brains of flies, fish, and mice. Similar strategies can be harnessed to develop a plethora of GRAB sensors for other important neurotransmitters/neuromodulators.
Click here for more information: http://wpi-iiis.tsukuba.ac.jp/seminar
|Contact||International Institute for Integrative Sleep Medicine
Phone: 029-853-8080 (ext.8080)
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