|Date and time||27 June 2018, Wednesday, 09:00 - 10:00|
|Venue||1F Auditorium, IIIS Building, University of Tsukuba|
|Access||Take a bus bound for "Tsukuba Daigaku Chuo" or the "University Loop-line On-campus Bus [Tsukuba Daigaku Junkan Bus]" and get off at Oikoshi Gakusei Shukusha Mae|
|Speaker|| Dr. Patrick M. Fuller, Harvard Medical School and Department of Neurology, Beth Israel Deaconess Medical Center
|Title||The circuit and synaptic basis of arousal and sleep|
|Abstract||The focus of my laboratory’s investigative activities has been the cellular and synaptic bases by which the brain regulates sleep, wakeful consciousness and circadian rhythms. In my seminar, I will discuss some of the experimental outcomes of these investigative activities, which includes our “top-down” reassessment of the structural basis of the brain’s arousal network, a genetically-driven “dissection” of the cellular basal forebrain, the identification and characterization of a previously unrecognized brainstem circuit that is both necessary and sufficiency to produce slow-wave-sleep and cortical slow-wave-activity, the identification of a hitherto unknown inhibitory hypothalamic-preoptic circuit that promotes arousal, and our most recent work showing that the caudal hypothalamus contains a delimited node of glutamatergic, NOS1-expressing neurons that can conjointly drive cortical and hippocampal activation and behavioral arousal. Finally, I will describe on-going experimental work that seeks to understand how the cellular suprachiasmatic nucleus imparts temporal organization on the sleep-wake cycle. Together these studies, along with a large number of other findings by laboratories around the world, have provided key insights into the circuit and synaptic mechanisms by which the brain regulates behavioral state.
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