• The 444th TSMM seminar

    08 07, 2018

    Date and timeAugust 7 Tuesday 2018, 17:00-18:00
    VenueIgaku Gakkei-to Room 483
    TitleTowards understanding the regulatory mechanisms of unconventional kinetochore proteins.
    SpeakerDr. Midori Ishii, Department of Biochemistry, University of Oxford
    AbstractFaithful chromosome segregation is essential for the survival of all eukaryotic cells. The kinetochore is a macromolecular protein complex that drives chromosome segregation during mitosis. Trypanosoma brucei is a unicellular flagellated eukaryote that is evolutionarily distant from common model eukaryotes such as yeasts and humans. Although basic cell- cycle machinery is conserved in T. brucei, it does not have any canonical kinetochore protein found in essentially all other sequenced eukaryotes. Instead T. brucei has at least twenty unconventional kinetochore proteins, called KKT1?20 and KKIP1?7. So far very little is known about the structure, function, and regulation of these components, and it remains unknown how they assemble onto the centromere to build mature kinetochores during mitosis. To address these questions, I have focused on two of these unconventional kinetochore proteins, KKT10 and KKT19 which have a kinase domain and might have regulatory roles. In this seminar, I will talk about recent results about KKT10/19 functions.
    ContactKenji IRIE
    Extension 3066
    E-mail: kirie[ ]
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