• The 140th WPI-IIIS seminar

    12 07, 2018

    Date Friday, December 7, 2018
    Time 12:00 –13:00
    Venue 1F Auditorium, IIIS Building, University of Tsukuba
    Access Take a bus bound for "Tsukuba Daigaku Chuo" or the "University Loop-line On-campus Bus [Tsukuba Daigaku Junkan Bus]" and get off at Oikoshi Gakusei Shukusha Mae
    Speaker Dr.Hiroshi Yamaguchi, Dept. of Psychiatry and Behavioral Sciences, Stanford University School of Medicine
    Subject Hypothalamic control of mouse daily torpor / cell type-specific CRISPR gene editing in the adult brain
    Summary In this seminar, I will talk about two topics, the neuronal mechanism of daily torpor and CRISPR gene editing in the adult brain. Hibernators save energy by entering torpor, a state characterized by active hypometabolism and low body temperature, to survive harsh environmental conditions in winter. Torpor can be found in a wide variety of homeothermic animals including birds, rodents and primates. Laboratory mice go into short torpid state called daily torpor when they are fasted at cold ambient temperature. Although it is presumed that torpor is regulated by the central nervous system, the exact neuronal mechanism by which mice regulate daily torpor remains unclear. Our recent studies revealed that the activities of neurons in the medial preoptic hypothalamus and the dorsomedial hypothalamus are essential for the induction of torpor. Next, I will talk about our recent data showing the proof-of-principle that cell type-specific CRISPR gene editing in adult neurons can be used to interrogate gene function within genetically-defined neuronal circuitry associated with complex behaviors like sleep.

    Click here for more information:
    Contact International Institute for Integrative Sleep Medicine
    Phone: 029-853-8080 (ext.8080)

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