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  • The 166th WPI-IIIS seminar

    01 22, 2020
    Date Wednesday, January 22, 2020
    Time 12:00 -13:00
    Venue 1F Auditorium, IIIS Building, University of Tsukuba
    Access Take a bus bound for "Tsukuba Daigaku Chuo" or the "University Loop-line On-campus Bus [Tsukuba Daigaku Junkan Bus]" and get off at Oikoshi Gakusei Shukusha Mae
    Speaker Dr. Juro Sakai
    Tohoku University School of Medicine / The University of Tokyo, Research Center of Advanced Science and Technology (RCAST)
    Subject “A Concerted Thermogenic Response via a Phosphor-Switch of an Epigenetic Modifier”
    Summary How cells sense and respond to environmental cues remains a central question of biological research. Recent evidence suggests that chromatin organization called epigenetics regulates cell fate. Fat cells play important roles in protecting organisms against starvation and cold environment. While brown fat cells burn fat to produce heat in acute cold exposure, under chronic cold environment, brown-like fat cells called “beige fat cells” are recruited in subcutaneous white adipose tissue (scWAT) and actively burn fat for heat production. This adaptive change is called scWAT “beige-ing” and contributes to chronic adaptation. In the present talk, I will present how β-adrenergic signaling, implicated in acute stress response, downstream of sympathetic nerve stimulation, regulates concerted thermogenic response in brown adipose tissue and scWAT via the epigenetic mechanism.

    Click here for more information: http://wpi-iiis.tsukuba.ac.jp/seminar
    Contact International Institute for Integrative Sleep Medicine
    Phone: 029-853-5857 (ext.5857)


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