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Researchers at University of Tsukuba have found that thiamine (vitamin B1) tetrahydrofurfuryl disulfide (TTFD), a common thiamine derivative, can induce arousal. TTFD is chemically modified to improve tissue penetration and absorption and is recognized for enhancing motivation for physical activity. In a recent study, this derivative was administered to rats, and its effect on sleep-wake states was assessed using electroencephalography (EEG). The results indicated that TTFD promoted arousal.

Tsukuba, Japan—Thiamine deficiency has long been a significant health concern, contributing to conditions such as beriberi, which was widespread from the Edo to Meiji periods (1868-1912). The development of thiamine derivatives in the 1950s marked a key advance in treating these deficiencies. Today, such derivatives are commonly used as nutritional supplements to support daily energy, even in modern societies where thiamine deficiency is uncommon. Recent studies have also examined the potential effects of thiamine derivatives on brain function.

The research team previously discovered that TTFD increases dopamine levels in the medial prefrontal cortex of rats, thereby boosting physical activity. This rise in dopamine is linked to the activation of brain regions involved in arousal, such as the ventral tegmental area and the locus coeruleus. Based on these findings, the team hypothesized that TTFD administration would promote arousal.

To test this hypothesis, the team intraperitoneally administered TTFD to rats and assessed changes in their sleep-wake states and physical activity levels using EEG and electromyography. The results indicated that TTFD administration enhanced physical activity and wakefulness. Future studies will aim to uncover the neural mechanisms behind this effect, potentially demonstrating TTFD's potential in boosting daily vitality.

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This research was supported in part by KAKENHI Grants-in-Aid for Scientific Research (A) (21H04858; 24H00670) (H. Soya); Scientific Research (C) (22K11601) (F. Grenier); Scientific Research on Innovative Areas: Next Generation Exercise Program for Developing Motivation, Body and Mind Performance (16H06405) (H. Soya); Japan Science and Technology Agency (JST)-Mirai Program (JPMJMI19D5) (H. Soya); Grant-in-Aid for Japan Society for the Promotion of Science Fellowships (21J20478; 22KJ0362) (T. Hata); and a joint research grant from NIHON PHARMACEUTICAL Co., Ltd (H. Soya).

Original Paper

Title of original paper:

Promoting arousal associated with physical activity with the vitamin B1 derivative TTFD

Journal:

The Journal of Physiological Sciences

DOI:

10.1016/j.jphyss.2024.100001

Correspondence

Visiting Professor SOYA Hideaki
Center for Cybernics Research, University of Tsukuba
Professor Emeritus, Institute of Health and Sport Sciences, University of Tsukuba

Related Link

Institute of Health and Sport Sciences

Center for Cybernics Research